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Gamma benzene hexachloride is a central nervous system stimulant when absorbed systemically. Following absorption through the chitinous exoskeleton of arthropods, Gamma benzene hexachloride is presumed to stimulate the nervous system, resulting in convulsions and death. Lotion—In one study, a mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of Gamma benzene hexachloride lotion for scabies. In one study, the half-life of lindane was 18 hours in infants and children treated for scabies using total body application of Gamma benzene hexachloride lotion. Studies in animals have not shown Gamma benzene hexachloride to have carcinogenic properties.
In one study, despite the high incidence of tumors in the control group, Gamma benzene hexachloride was thought to be associate Adequate and well-controlled studies in humans have not been done. Because lindane is absorbed through the skin and has the potential for causing CNS toxicity, some clinicians do not recommend the use of Gamma benzene hexachloride during pregnancy. If Gamma benzene hexachloride is used, however, the recommended dosage should not be exceeded in pregnant women, and these women should not be treated more than twice during pregnancd with a significant increase in the incidence of hepatoma
Problems in humans have not been documented; however, Gamma benzene hexachloride is systemically absorbed and is distributed into breast milk. Although the concentrations found in human blood following topical application of Gamma benzene hexachloride make it unlikely that breast milk will contain amounts of Gamma benzene hexachloride sufficient to cause toxicity, an alternate method of feeding the infant should be used for 2 days.